publications

Edelblum KL, Turner JR; The tight junction in inflammatory disease: communication breakdown;  Current Opinion in Pharmacology, 9(6):715-20, 2009

Edelblum KL, Shen L, Weber CR, Marchiando AM, Clay BS, Wang Y, Prinz I, Malissen B, Sperling AI, Turner JR; Dynamic migration of gamma delta intraepithelial lymphocytes requires occludin; Proceedings of the National Academy of Sciences, 109(18):7097-102, 2012

Nalle SC, Kwak HA, Edelblum KL, Joseph NE, Singh G, Khramtsova GF, Mortenson ED, Savage PA, Turner JR; Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease; Science Translational Medicine, 6(243):243ra87, 2014

Edelblum KL, Singh G, Odenwald MA, Lingaraju A, El Bissati K, McLeod R, Sperling AI, Turner JR; gamma delta intraepithelial lymphocyte migration limits transepithelial pathogen invasion and systemic disease in mice. Gastroenterology. 2015 Jun;148(7):1417-26. 

Edelblum KL, Sharon G, Singh G, Odenwald MA, Sailer A, Cao S, Ravens S, Thomsen I, El Bissati K, McLeod R, Dong C, Gurbuxani S, Prinz I, Mazmanian SK, Turner JR; The microbiome activates CD4 T-cell-mediated immunity to compensate for increased intestinal permeability. Cell Mol Gastroenterol Hepatol. 2017 Jun 10;4(2):285-297.

Hu MD, Edelblum KL; Sentinels at the Frontline: Intraepithelial Lymphocytes and Inflammatory Bowel Disease. Curr Pharmacol Rep. 2017 Dec;3(6):321-334.

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Pearce SC, Al-Jawadi A, Kishida K, Yu S, Hu M, Fritzky LF, Edelblum KL, Gao N, Ferraris RP; Marked  differences in tight junction composition and macromolecular permeability among different intestinal cell types. BMC Biol. 2018 Feb 1;16(1):19.

Hu MD, Jia L, Edelblum KL; Policing the intestinal epithelial barrier: Innate immune functions of intraepithelial lymphocytes. Curr Pathobiol Rep. 2018 Mar; 6(1):35-46.

Hu MD, Ethridge AD, Lipstein R, Kumar S, Wang Y, Jabri B, Turner JR, Edelblum KL; Epithelial IL-15 is a critical regulator of gamma delta intraepithelial lymphocyte motility within the intestinal mucosa. J Immunol. 2018 Jun 8. pii: ji1701603.

 Jia L and Edelblum KL; Intravital Imaging of Murine Intestinal Intraepithelial Lymphocytes. J Vis Exp. 2019 Jun 24;(148). 

Fischer MA, Golovchenko NB, Edelblum KL. Gamma delta T cell migration: Separating trafficking from surveillance behaviors at barrier surfaces. Immunol Rev. 2020 Nov;298(1):165-180.

Hu MD, Golovchenko NB, Burns GL, Nair PM, Kelly TJ 4th, Agos J, Irani MZ, Soh WS, Zeglinski MR, Lemenze A, Bonder EM, Sandrock I, Prinz I, Granville DJ, Keely S, Watson AJM, Edelblum KL. γδ intraepithelial lymphocytes facilitate pathological epithelial cell shedding via CD103-mediated granzyme release. Gastroenterology. 2022 Mar;162(3):877-889. 

Jia L*, Wu G*, Alonso S, Zhao C, Lemenze A, Lam YY, Zhao L, Edelblum KL; A transmissible γδ intraepithelial lymphocyte hyperproliferative phenotype is associated with the intestinal microbiota and confers protection against acute infection. Mucosal Immunol. In press.