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Edelblum Lab

 IBD research laboratory at Mount Sinai School of Medicine studying immune/epithelial interactions to better understand the underlying causes of Crohn's disease and discover potential new areas for therapeutic development

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3.1 million Americans

LIVE WITH INFLAMMATORY BOWEL DISEASE

Crohn's disease and ulcerative colitis affect 1.3% of the population with 70,000 new cases diagnosed every year. IBD is caused by a combination of genetic and environmental factors that lead to an abnormal immune reaction to the normal bacteria found in the intestine.

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projects.

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We are looking for someone with CRC experience that would like to help continue to build our translational research program. Apply using the link above.

May 2026

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After three years of extensive image analysis, Dylan wrapped up his Advanced Science Research project focusing on microbiota-induced γδ IEL/macrophage interactions.

May 2026

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It's surprising how little is known about how the microbiota influences γδ T cell biology. In a new review in Gut Microbes,  Ananya and Tingting wrote a primer on what is known about the relationships between commensals and γδ T cells within each compartment of the intestinal mucosa. 

December 2025

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We report in our latest publication in Mucosal Immunology  that a unique microbiota that induces expansion of the γδ IEL compartment also upregulates CD39 expression through TCR and IL-15 signaling. Congratulations to Sara (along with Andrew, Jack and Alyssa) on a fantastic story! 

August 2025

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Our latest publication in Science Immunology  shows that multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis. Congrats to Weili and Natasha (with an assist from Irving) on their hard work!

March 21, 2025

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We're ready to rally and be part of the large movement to ensure that biomedical research continues to thrive in the United States. Come join us in Washington Square Park and show your support of NIH, CDC, NSF and the other government agencies that fund the basic science research that is fundamental to human health!

March 7, 2025

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Copyright 2017 Karen Edelblum

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