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Edelblum Lab

 IBD research laboratory at Mount Sinai School of Medicine studying immune/epithelial interactions to better understand the underlying causes of Crohn's disease and discover potential new areas for therapeutic development

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3.1 million Americans

LIVE WITH INFLAMMATORY BOWEL DISEASE

Crohn's disease and ulcerative colitis affect 1.3% of the population with 70,000 new cases diagnosed every year. IBD is caused by a combination of genetic and environmental factors that lead to an abnormal immune reaction to the normal bacteria found in the intestine.

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Check out our latest publication in Journal of Immunology  showing that type I IFN promotes gamma delta IEL antimicrobial responses through TCR-independent and -dependent mechanisms. Congrats to Matt on this highly mechanistic study!

September 2024

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After a successful defense, we're excited to see what discoveries in immune/epithelial biology Natasha will make during her postdoc with Chuck Parkos & Asma Nusrat at UMichigan.

October 2024

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We're excited to welcome our new lab manager Noah Grunberg, Sayra Garcia (postdoc) and Tingting Li (instructor) to the wonderful world of gamma delta IELs!

October 2024

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Thank you to everyone who donated or joined us at the NYC Take Steps Walk! With your help we raised enough to support one undergraduate summer research fellowship!

June 2024

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In a preprint available on bioRxiv, we show multiple layers of dysregulation within the gamma delta IEL compartment prior to the onset of Crohn's disease-like ileitis suggesting that altered gamma delta IEL biology may be a useful biomarker for disease relapse or response to therapy.

August 2023

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Are you an incoming graduate student at ISMMS? Are you looking for a mucosal immunology lab that incorporates basic and translational research? Do you appreciate a lab that supports a healthy work/life balance? Do you like snacks? If so, we might be the lab for you! Contact us below about a rotation.

Summer 2024

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